The CD160+ CD8high cytotoxic T cell subset correlates with response to HAART in HIV-1+ patients

MH Nikolova, MN Muhtarova, HB Taskov, K Kostov… - Cellular …, 2005 - Elsevier
We investigated the circulating cytotoxic CD160+ CD8high subset in correlation to antiviral
immunity and response to highly active antiretroviral therapy (HAART) in HIV+ subjects. The
study included 45 treatment-naive patients receiving HAART for 18 months, retrospectively
defined as good (n= 29) and transient (n= 16) responders. HIV-specific CD8 T lymphocyte
levels were measured by IFNγ production in response to p17 Gag, in the presence of
immobilized anti-CD160 mAb. We report a significantly increased baseline level of CD160+ …