[HTML][HTML] Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA
A Narayanan, S Iordanskiy, R Das, R Van Duyne… - Journal of Biological …, 2013 - ASBMB
Exosomes are nano-sized vesicles produced by healthy and virus-infected cells. Exosomes
derived from infected cells have been shown to contain viral microRNAs (miRNAs). HIV-1
encodes its own miRNAs that regulate viral and host gene expression. The most abundant
HIV-1-derived miRNA, first reported by us and later by others using deep sequencing, is the
trans-activation response element (TAR) miRNA. In this study, we demonstrate the presence
of TAR RNA in exosomes from cell culture supernatants of HIV-1-infected cells and patient …
derived from infected cells have been shown to contain viral microRNAs (miRNAs). HIV-1
encodes its own miRNAs that regulate viral and host gene expression. The most abundant
HIV-1-derived miRNA, first reported by us and later by others using deep sequencing, is the
trans-activation response element (TAR) miRNA. In this study, we demonstrate the presence
of TAR RNA in exosomes from cell culture supernatants of HIV-1-infected cells and patient …