[HTML][HTML] Identification of SNF1/AMP kinase-related kinase as an NF-κB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness

P Legembre, R Schickel, BC Barnhart… - Journal of Biological …, 2004 - ASBMB
The death receptor CD95 (APO-1/Fas) induces apoptosis in many tissues. However, in
apoptosis-resistant tumor cells, stimulation of CD95 induces up-regulation of a defined
number of mostly anti-apoptotic genes, resulting in increased motility and invasiveness of
tumor cells. The majority of these genes are known NF-κB target genes. We have identified
one of the CD95-regulated genes as the serine/threonine kinase (SNF1/AMP kinase-related
kinase (SNARK)), which is induced in response to various forms of metabolic stress. We …