AMP kinase in exercise adaptation of skeletal muscle
N Jessen, EIO Sundelin, AB Møller - Drug discovery today, 2014 - Elsevier
N Jessen, EIO Sundelin, AB Møller
Drug discovery today, 2014•ElsevierHighlights•AMPK is involved in regulating protein synthesis and degradation.•
Pharmacological AMPK activation in animals can mimic adaptations to exercise
training.•Adaptation to exercise training is reliant on normally regulated autophagy.•ULK1 is
a crucial direct intermediate in AMPK-mediated autophagy.Regular physical exercise has
undisputed health benefits in the prevention and the treatment of many diseases.
Understanding the mechanisms that regulate adaptations to exercise training therefore has …
Pharmacological AMPK activation in animals can mimic adaptations to exercise
training.•Adaptation to exercise training is reliant on normally regulated autophagy.•ULK1 is
a crucial direct intermediate in AMPK-mediated autophagy.Regular physical exercise has
undisputed health benefits in the prevention and the treatment of many diseases.
Understanding the mechanisms that regulate adaptations to exercise training therefore has …
Highlights
- AMPK is involved in regulating protein synthesis and degradation.
- Pharmacological AMPK activation in animals can mimic adaptations to exercise training.
- Adaptation to exercise training is reliant on normally regulated autophagy.
- ULK1 is a crucial direct intermediate in AMPK-mediated autophagy.
Regular physical exercise has undisputed health benefits in the prevention and the treatment of many diseases. Understanding the mechanisms that regulate adaptations to exercise training therefore has obvious clinical perspectives. Several lines of evidence suggest that the AMP-activated protein kinase (AMPK) has a central role as a master metabolic regulator in skeletal muscle. Exercise is a potent activator of AMPK, and AMPK signaling can play a key part in regulating protein turnover during and after exercise training.
Elsevier