[HTML][HTML] Circulating FGF-23 is regulated by 1α, 25-dihydroxyvitamin D3 and phosphorus in vivo
H Saito, A Maeda, S Ohtomo, M Hirata… - Journal of Biological …, 2005 - ASBMB
Fibroblast growth factor-23 (FGF-23), a novel phosphate-regulating factor, was elevated in
hypophosphatemic patients with X-linked hypophosphatemic rickets/osteomalacia and also
in patients with chronic kidney disease. These observations suggested the
pathophysiological importance of FGF-23 on phosphate homeostasis. However, regulation
of FGF-23 production is still unclear. We investigated effects of both dietary phosphorus and
1α, 25-dihydroxyvitamin D 3 (1α, 25 (OH) 2 D 3) on circulating FGF-23 in vivo Administration …
hypophosphatemic patients with X-linked hypophosphatemic rickets/osteomalacia and also
in patients with chronic kidney disease. These observations suggested the
pathophysiological importance of FGF-23 on phosphate homeostasis. However, regulation
of FGF-23 production is still unclear. We investigated effects of both dietary phosphorus and
1α, 25-dihydroxyvitamin D 3 (1α, 25 (OH) 2 D 3) on circulating FGF-23 in vivo Administration …