Managing antiretroviral therapy (ART)–experienced individuals requires a systematic
approach in order to optimize outcomes. Consideration must be given to the different
reasons for switching or modifying therapy in a given person. These reasons range from the
management of suboptimal virologic response, poor tolerability, to enhance convenience, or
to minimize interactions with other medications or food. This article categorizes individuals
as those planning to modify therapy for suboptimal virologic response or while maintaining …