HIV persistence: chemokines and their signalling pathways
VA Evans, G Khoury, S Saleh, PU Cameron… - Cytokine & growth factor …, 2012 - Elsevier
Latently infected resting CD4+ T cells are the major barrier to curing HIV. We have recently
demonstrated that chemokines, which bind to the chemokine receptors CCR7, CXCR3 and
CCR6, facilitate efficient HIV nuclear localisation and integration in resting CD4+ T cells,
leading to latency. As latently infected cells are enriched in lymphoid tissues, where
chemokines are highly concentrated, this may provide a mechanism for the generation of
latently infected cells in vivo. Here we review the role of chemokines in HIV persistence; the …
demonstrated that chemokines, which bind to the chemokine receptors CCR7, CXCR3 and
CCR6, facilitate efficient HIV nuclear localisation and integration in resting CD4+ T cells,
leading to latency. As latently infected cells are enriched in lymphoid tissues, where
chemokines are highly concentrated, this may provide a mechanism for the generation of
latently infected cells in vivo. Here we review the role of chemokines in HIV persistence; the …