[HTML][HTML] Clock genes influence gene expression in growth plate and endochondral ossification in mice

T Takarada, A Kodama, S Hotta, M Mieda… - Journal of Biological …, 2012 - ASBMB
We have previously shown transient promotion by parathyroid hormone of Period-1 (Per1)
expression in cultured chondrocytes. Here we show the modulation by clock genes of
chondrogenic differentiation through gene transactivation of the master regulator of
chondrogenesis Indian hedgehog (IHH) in chondrocytes of the growth plate. Several clock
genes were expressed with oscillatory rhythmicity in cultured chondrocytes and rib growth
plate in mice, whereas chondrogenesis was markedly inhibited in stable transfectants of …