CD73 expression as a potential marker of good prognosis in breast carcinoma
A Supernat, A Markiewicz… - Applied …, 2012 - journals.lww.com
Abstract Ecto-5′-nucleotidase (CD73) is a membrane-bound enzyme, which catalyzes the
conversion of adenosine monophosphate to adenosine. CD73 has been postulated to play
an important role in carcinogenesis, as adenosine promotes tumor progression and CD73-
expressing cancer cell lines are more aggressive. However, other studies have shown that
activated adenosine receptors may also inhibit cell proliferation. This study investigated the
clinical significance of CD73 expression in breast cancer. The study group included 136 …
conversion of adenosine monophosphate to adenosine. CD73 has been postulated to play
an important role in carcinogenesis, as adenosine promotes tumor progression and CD73-
expressing cancer cell lines are more aggressive. However, other studies have shown that
activated adenosine receptors may also inhibit cell proliferation. This study investigated the
clinical significance of CD73 expression in breast cancer. The study group included 136 …