King of hearts: a splicing factor rules cardiac proteins

WA Linke, S Bücker - Nature medicine, 2012 - nature.com
WA Linke, S Bücker
Nature medicine, 2012nature.com
Alternative splicing ensures the expression of functionally diverse proteins from individual
genes; however, aberrant mRNA splicing is associated with various conditions, including
heart disease. A recent study provides new mechanistic insights into heart failure by
showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-
transcriptional regulation, causing the expression of anomalous isoforms of a whole network
of cardiac proteins (pages 766–773).
Alternative splicing ensures the expression of functionally diverse proteins from individual genes; however, aberrant mRNA splicing is associated with various conditions, including heart disease. A recent study provides new mechanistic insights into heart failure by showing that a human cardiomyopathy-linked mutation in a cardiac splice factor affects post-transcriptional regulation, causing the expression of anomalous isoforms of a whole network of cardiac proteins (pages 766–773).
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