[HTML][HTML] Proinflammatory cytokine tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) suppresses satellite cell self-renewal through inversely …

Y Ogura, V Mishra, SM Hindi, S Kuang… - Journal of Biological …, 2013 - ASBMB
Satellite cell self-renewal is an essential process to maintaining the robustness of skeletal
muscle regenerative capacity. However, extrinsic factors that regulate self-renewal of
satellite cells are not well understood. Here, we demonstrate that TWEAK cytokine reduces
the proportion of Pax7+/MyoD− cells (an index of self-renewal) on myofiber explants and
represses multiple components of Notch signaling in satellite cell cultures. The number of
Pax7+ cells is significantly increased in skeletal muscle of TWEAK knock-out (KO) mice …