The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting
H Maeda - Advances in enzyme regulation, 2001 - Elsevier
Increasing attention has been paid in recent years to tumor angiogenesis and its control,
with a focus on vascular endothelial growth factor (VEGF). Inhibition of angiogenesis by
various antidotes or inhibitors such as endostatin and angiostatin is the most exciting issue
in tumor biology, and for patients longing for a cure for cancer. Tumor vascular permeability
factor (VPF) was initially identified by Senger et al. in the laboratory of Dvorak (1) and was
later confirmed as identical to VEGF (2–5). Although more attention has been focused on …
with a focus on vascular endothelial growth factor (VEGF). Inhibition of angiogenesis by
various antidotes or inhibitors such as endostatin and angiostatin is the most exciting issue
in tumor biology, and for patients longing for a cure for cancer. Tumor vascular permeability
factor (VPF) was initially identified by Senger et al. in the laboratory of Dvorak (1) and was
later confirmed as identical to VEGF (2–5). Although more attention has been focused on …