Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities
YA Valentin-Vega, N Box, T Terzian, G Lozano - Differentiation, 2009 - Elsevier
Mdm4 is a critical inhibitor of the p53 tumor suppressor. Mdm4 null mice die early during
embryogenesis due to increased p53 activity. In this study, we explore the role that Mdm4
plays in the intestinal epithelium by crossing mice carrying the Mdm4 floxed allele to mice
with the Villin Cre transgene. Our data show that loss of Mdm4 (Mdm4intΔ) in this tissue
resulted in viable animals with no obvious morphological abnormalities. However, these
mutants displayed increased p53 levels and apoptosis exclusively in the proliferative …
embryogenesis due to increased p53 activity. In this study, we explore the role that Mdm4
plays in the intestinal epithelium by crossing mice carrying the Mdm4 floxed allele to mice
with the Villin Cre transgene. Our data show that loss of Mdm4 (Mdm4intΔ) in this tissue
resulted in viable animals with no obvious morphological abnormalities. However, these
mutants displayed increased p53 levels and apoptosis exclusively in the proliferative …