Mdmx as an essential regulator of p53 activity
JC Marine, AG Jochemsen - Biochemical and biophysical research …, 2005 - Elsevier
JC Marine, AG Jochemsen
Biochemical and biophysical research communications, 2005•ElsevierThe murine double minute 2 (Mdm2) is a critical negative regulator of the p53 tumor
suppressor. Almost 10 years ago, a search for new p53-interactors revealed the existence of
an Mdm2-structurally related protein, Mdmx (or Mdm4). Since then a large body of
biochemical data has accumulated on the functions of Mdmx, often leading to conflicting
molecular models. Nevertheless, virtually all these data pointed toward a critical role for
Mdmx in the regulation of the p53–Mdm2 network. A view that was recently confirmed by …
suppressor. Almost 10 years ago, a search for new p53-interactors revealed the existence of
an Mdm2-structurally related protein, Mdmx (or Mdm4). Since then a large body of
biochemical data has accumulated on the functions of Mdmx, often leading to conflicting
molecular models. Nevertheless, virtually all these data pointed toward a critical role for
Mdmx in the regulation of the p53–Mdm2 network. A view that was recently confirmed by …
The murine double minute 2 (Mdm2) is a critical negative regulator of the p53 tumor suppressor. Almost 10 years ago, a search for new p53-interactors revealed the existence of an Mdm2-structurally related protein, Mdmx (or Mdm4). Since then a large body of biochemical data has accumulated on the functions of Mdmx, often leading to conflicting molecular models. Nevertheless, virtually all these data pointed toward a critical role for Mdmx in the regulation of the p53–Mdm2 network. A view that was recently confirmed by genetic studies. This review is a summary of our current understanding of this molecule, its structure and biological functions, as well as its relationship to its known binding partners.
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