Aortic pulse wave velocity predicts cardiovascular mortality in subjects> 70 years of age

S Meaume, A Benetos, OF Henry… - … , and vascular biology, 2001 - Am Heart Assoc
S Meaume, A Benetos, OF Henry, A Rudnichi, ME Safar
Arteriosclerosis, thrombosis, and vascular biology, 2001Am Heart Assoc
Aortic pulse wave velocity (PWV) is a significant and independent predictor of
cardiovascular mortality in subjects with essential hypertension and in patients with end-
stage renal disease. Its contribution to cardiovascular risk in subjects 70 to 100 years old
has never been tested. A cohort of 141 subjects (meanąSD age, 87.1ą6.6 years) was
studied in 3 geriatrics departments in a Paris suburb. Together with sphygmomanometric
blood pressure measurements, aortic PWV was measured with a validated automatic …
Aortic pulse wave velocity (PWV) is a significant and independent predictor of cardiovascular mortality in subjects with essential hypertension and in patients with end-stage renal disease. Its contribution to cardiovascular risk in subjects 70 to 100 years old has never been tested. A cohort of 141 subjects (meanąSD age, 87.1ą6.6 years) was studied in 3 geriatrics departments in a Paris suburb. Together with sphygmomanometric blood pressure measurements, aortic PWV was measured with a validated automatic device. During the 30-month follow-up, 56 patients died (27 from cardiovascular events). Logistic regressions indicated that age (P=0.005) and a loss of autonomy (P=0.01) were the best predictors of overall mortality. For cardiovascular mortality, aortic PWV was the major risk predictor (P=0.016). The odds ratio was 1.19 (95% confidence interval, 1.03 to 1.37). Antihypertensive drug treatment and blood pressure, including systolic and pulse pressure, had no additive role. In subjects 70 to 100 years old, aortic PWV is a strong, independent predictor of cardiovascular death, whereas systolic or pulse pressure was not. This prospective result will need to be confirmed in an intervention trial.
Am Heart Assoc