[HTML][HTML] Three novel collagen VI chains, α4 (VI), α5 (VI), and α6 (VI)

J Fitzgerald, C Rich, FH Zhou, U Hansen - Journal of biological chemistry, 2008 - ASBMB
We report the identification of three new collagen VI genes at a single locus on human
chromosome 3q22. 1. The three new genes are COL6A4, COL6A5, and COL6A6 that
encode the α4 (VI), α5 (VI), and α6 (VI) chains. In humans, the COL6A4 gene has been
disrupted by a chromosome break. Each of the three new collagen chains contains a 336-
amino acid triple helix flanked by seven N-terminal von Willebrand factor A-like domains and
two (α4 and α6 chains) or three (α5 chain) C-terminal von Willebrand factor A-like domains …