Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Gαs and Gαi/Gαo activation
M Hällbrink, T Holmqvist, M Olsson… - … et Biophysica Acta (BBA …, 2001 - Elsevier
It has previously been shown that the GLP-1 receptor is primarily coupled to the adenylate
cyclase pathway via activation of Gαs proteins. Recent studies have shown that the third
intracellular loop of the receptor is important in the stimulation of cAMP production. We have
studied the effect of three synthetic peptide sequences derived from the third intracellular
loop of the GLP-1 receptor on signal transduction in Rin m5F cell membranes. The whole
third intracellular loop strongly stimulates both pertussis toxin and cholera toxin-sensitive G …
cyclase pathway via activation of Gαs proteins. Recent studies have shown that the third
intracellular loop of the receptor is important in the stimulation of cAMP production. We have
studied the effect of three synthetic peptide sequences derived from the third intracellular
loop of the GLP-1 receptor on signal transduction in Rin m5F cell membranes. The whole
third intracellular loop strongly stimulates both pertussis toxin and cholera toxin-sensitive G …