[HTML][HTML] Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma
Journal of clinical oncology: official journal of the American Society …, 2002•ncbi.nlm.nih.gov
Results The maximum-tolerated dose was 3× 10 8 cfu/m². Dose-limiting toxicity was
observed in patients receiving 1× 10 9 cfu/m², which included thrombocytopenia, anemia,
persistent bacteremia, hyperbilirubinemia, diarrhea, vomiting, nausea, elevated alkaline
phosphatase, and hypophosphatemia.
observed in patients receiving 1× 10 9 cfu/m², which included thrombocytopenia, anemia,
persistent bacteremia, hyperbilirubinemia, diarrhea, vomiting, nausea, elevated alkaline
phosphatase, and hypophosphatemia.
Results
The maximum-tolerated dose was 3× 10 8 cfu/m². Dose-limiting toxicity was observed in patients receiving 1× 10 9 cfu/m², which included thrombocytopenia, anemia, persistent bacteremia, hyperbilirubinemia, diarrhea, vomiting, nausea, elevated alkaline phosphatase, and hypophosphatemia.
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