Characterization of the Hanganutziu-Deicher (serum-sickness) antigen as gangliosides containing N-glycolylneuraminic acid

JM Merrick, K Zadarlik, F Milgrom - International Archives of Allergy and …, 1978 - karger.com
JM Merrick, K Zadarlik, F Milgrom
International Archives of Allergy and Immunology, 1978karger.com
Gangliosides that possess the same sugar sequence but differing in the type of sialic acid (N-
acetyl-or N-glycolylneuraminic acid) were compared for their reactivity with Hanganutziu-
Deicher ('serum sickness') antibodies by double-diffusion gel precipitation tests. Only N-
glycolylneuraminic acid containing gangliosides formed precipitation lines with Hanganutziu-
Deicher antibodies, thus suggesting that Hanganutziu-Deicher antigens are gangliosides
that contain N-glycolylneuraminic acid.
Abstract
Gangliosides that possess the same sugar sequence but differing in the type of sialic acid (N-acetyl- or N-glycolylneuraminic acid) were compared for their reactivity with Hanganutziu-Deicher (‘serum sickness’) antibodies by double-diffusion gel precipitation tests. Only N-glycolylneuraminic acid containing gangliosides formed precipitation lines with Hanganutziu-Deicher antibodies, thus suggesting that Hanganutziu-Deicher antigens are gangliosides that contain N-glycolylneuraminic acid.
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