Angiotensin II stimulates vacuolar H+-ATPase activity in renal acid-secretory intercalated cells from the outer medullary collecting duct

F Rothenberger, A Velic, PA Stehberger… - Journal of the …, 2007 - journals.lww.com
Final urinary acidification is mediated by the action of vacuolar H+-ATPases expressed in
acid-secretory type A intercalated cells (A-IC) in the collecting duct. Angiotensin II (AngII) has
profound effects on renal acid-base transport in the proximal tubule, distal tubule, and
collecting duct. This study investigated the effects on vacuolar H+-ATPase activity in A-IC in
freshly isolated mouse outer medullary collecting ducts. AngII (10 nM) stimulated
concanamycin-sensitive vacuolar H+-ATPase activity in A-IC in freshly isolated mouse outer …