[HTML][HTML] Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor

K Takayama, G Garcı́a-Cardeña, GK Sukhova… - Journal of Biological …, 2002 - ASBMB
Pro-inflammatory pathways participate in the pathogenesis of atherosclerosis. However, the
role of endogenous anti-inflammatory pathways in atheroma has received much less
attention. Therefore, using cDNA microarrays, we screened for genes regulated by
prostaglandin E 2 (PGE 2), a potential endogenous anti-inflammatory mediator, in
lipopolysaccharide (LPS)-treated human macrophages (MΦ). PGE 2 (50 nm) attenuated
LPS-induced mRNA and protein expression of chemokines including monocyte …