Excretion of platelet activating factor–acetylhydrolase and phospholipase A2 into nasal fluids after allergenic challenge: Possible role in the regulation of platelet …
L Touqui, N Herpin-Richard, RM Gene, E Jullian… - Journal of allergy and …, 1994 - Elsevier
Platelet activating factor (PAF), a proinflammatory mediator synthesized through a
phospholipase A 2 (PLA 2)-dependent reaction, is hydrolyzed into its inactive metabolite,
lyso-PAF, by a specific acetylhydrolase. Previous studies have shown that allergen
challenge of patients with allergic rhinitis leads to an increase of the concentrations of lyso-
PAF in nasal lavage fluid (NLF), whereas PAF is detected only marginally. PAF-hydrolyzing
enzymes are expected to be released on allergenic challenge, to account for the reduced …
phospholipase A 2 (PLA 2)-dependent reaction, is hydrolyzed into its inactive metabolite,
lyso-PAF, by a specific acetylhydrolase. Previous studies have shown that allergen
challenge of patients with allergic rhinitis leads to an increase of the concentrations of lyso-
PAF in nasal lavage fluid (NLF), whereas PAF is detected only marginally. PAF-hydrolyzing
enzymes are expected to be released on allergenic challenge, to account for the reduced …