Human hepatitis B virus surface and e antigens inhibit major vault protein signaling in interferon induction pathways

S Liu, N Peng, J Xie, Q Hao, M Zhang, Y Zhang… - Journal of …, 2015 - Elsevier
Background & Aims We previously demonstrated that major vault protein (MVP) is a novel
virus-induced host factor and its expression upregulates type-I interferon production, leading
to cellular antiviral response. However, it remains unclear whether the antiviral function of
MVP is impaired during hepatitis B virus (HBV) infection and what mechanisms are involved.
Therefore, the aim of this study was to assess whether HBV can alter MVP expression
despite the lack of type-I IFN induction and shed light on the underlying mechanisms HBV …