Strategies to eliminate HBV infection

R Kapoor, S Kottilil - Future virology, 2014 - Future Medicine
R Kapoor, S Kottilil
Future virology, 2014Future Medicine
Chronic HBV infection is a major public health concern affecting over 240 million people
worldwide. Although suppression of HBV replication is achieved in the majority of patients
with currently available newer antivirals, discontinuation of therapy prior to hepatitis B
surface antigen loss or seroconversion is associated with relapse of HBV in the majority of
cases. Thus, new therapeutic modalities are needed to achieve eradication of the virus from
chronically infected patients in the absence of therapy. The basis of HBV persistence …
Abstract
Chronic HBV infection is a major public health concern affecting over 240 million people worldwide. Although suppression of HBV replication is achieved in the majority of patients with currently available newer antivirals, discontinuation of therapy prior to hepatitis B surface antigen loss or seroconversion is associated with relapse of HBV in the majority of cases. Thus, new therapeutic modalities are needed to achieve eradication of the virus from chronically infected patients in the absence of therapy. The basis of HBV persistence includes viral and host factors. Here, we review novel strategies to achieve sustained cure or elimination of HBV. The novel approaches include targeting the viral and or host factors required for viral persistence, and novel immune-based therapies, including therapeutic vaccines.
Future Medicine