Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides
C Romeo, B Seed - Cell, 1991 - cell.com
C Romeo, B Seed
Cell, 1991•cell.comWe describe functional simplified T cell and Fc receptor chimeras that are capable of
directing CD8+ cytotoxic T lymphocytes (CTLs) to specifically recognize and lyse cells
expressing HIV envelope proteins. Target cells bearing HLA-DR molecules are not
recognized by CTL armed with the chimeras. The variety of cell types in which the native
receptors are active suggests multiple possibilities for antiviral intervention through genetic
means.
directing CD8+ cytotoxic T lymphocytes (CTLs) to specifically recognize and lyse cells
expressing HIV envelope proteins. Target cells bearing HLA-DR molecules are not
recognized by CTL armed with the chimeras. The variety of cell types in which the native
receptors are active suggests multiple possibilities for antiviral intervention through genetic
means.
Summary
We describe functional simplified T cell and Fc receptor chimeras that are capable of directing CD8+ cytotoxic T lymphocytes (CTLs) to specifically recognize and lyse cells expressing HIV envelope proteins. Target cells bearing HLA-DR molecules are not recognized by CTL armed with the chimeras. The variety of cell types in which the native receptors are active suggests multiple possibilities for antiviral intervention through genetic means.
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