[HTML][HTML] A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis
Abstract Interleukin-22 (IL-22) is a cytokine with epithelial reparative and regenerative
properties that is produced by Th22 cells and by other immune cell subsets. Therefore, we
explored the hypothesis that disruption of the gut barrier during HIV infection involves
dysregulation of these cells in the gastrointestinal mucosa. Sigmoid IL-22-producing T cell
and Th22 cells were dramatically depleted during chronic HIV infection, epithelial integrity
was compromised, and microbial translocation was increased. These alterations were …
properties that is produced by Th22 cells and by other immune cell subsets. Therefore, we
explored the hypothesis that disruption of the gut barrier during HIV infection involves
dysregulation of these cells in the gastrointestinal mucosa. Sigmoid IL-22-producing T cell
and Th22 cells were dramatically depleted during chronic HIV infection, epithelial integrity
was compromised, and microbial translocation was increased. These alterations were …