[HTML][HTML] A germ cell-specific gene, Prmt5, works in somatic cell reprogramming
G Nagamatsu, T Kosaka, M Kawasumi… - Journal of Biological …, 2011 - ASBMB
Germ cells possess the unique ability to acquire totipotency during development in vivo as
well as give rise to pluripotent stem cells under the appropriate conditions in vitro. Recent
studies in which somatic cells were experimentally converted into pluripotent stem cells
revealed that genes expressed in primordial germ cells (PGCs), such as Oct3/4, Sox2, and
Lin28, are involved in this reprogramming. These findings suggest that PGCs may be useful
for identifying factors that successfully and efficiently reprogram somatic cells into toti-and/or …
well as give rise to pluripotent stem cells under the appropriate conditions in vitro. Recent
studies in which somatic cells were experimentally converted into pluripotent stem cells
revealed that genes expressed in primordial germ cells (PGCs), such as Oct3/4, Sox2, and
Lin28, are involved in this reprogramming. These findings suggest that PGCs may be useful
for identifying factors that successfully and efficiently reprogram somatic cells into toti-and/or …