[HTML][HTML] Endothelial Krüppel-like factor 4 regulates angiogenesis and the Notch signaling pathway
AT Hale, H Tian, E Anih, FO Recio, MA Shatat… - Journal of Biological …, 2014 - ASBMB
Regulation of endothelial cell biology by the Notch signaling pathway (Notch) is essential to
vascular development, homeostasis, and sprouting angiogenesis. Although Notch
determines cell fate and differentiation in a wide variety of cells, the molecular basis of
upstream regulation of Notch remains poorly understood. Our group and others have
implicated the Krüppel-like factor family of transcription factors as critical regulators of
endothelial function. Here, we show that Krüppel-like factor 4 (KLF4) is a central regulator of …
vascular development, homeostasis, and sprouting angiogenesis. Although Notch
determines cell fate and differentiation in a wide variety of cells, the molecular basis of
upstream regulation of Notch remains poorly understood. Our group and others have
implicated the Krüppel-like factor family of transcription factors as critical regulators of
endothelial function. Here, we show that Krüppel-like factor 4 (KLF4) is a central regulator of …