[HTML][HTML] Peroxisome proliferator-activated receptor coactivator-1α (PGC-1α) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and-γ …

JM Huss, RP Kopp, DP Kelly - Journal of Biological Chemistry, 2002 - ASBMB
The transcriptional coactivator PPARγ coactivator-1α (PGC-1α) has been characterized as a
broad regulator of cellular energy metabolism. Although PGC-1α functions through many
transcription factors, the PGC-1α partners identified to date are unlikely to account for all of
its biologic actions. The orphan nuclear receptor estrogen-related receptor α (ERRα) was
identified in a yeast two-hybrid screen of a cardiac cDNA library as a novel PGC-1α-binding
protein. ERRα was implicated previously in regulating the gene encoding medium-chain …