[HTML][HTML] Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and Function*♦

M Maillet, J Davis, M Auger-Messier, A York… - Journal of biological …, 2010 - ASBMB
Calcineurin is a protein phosphatase that is uniquely regulated by sustained increases in
intracellular Ca 2+ following signal transduction events. Calcineurin controls cellular
proliferation, differentiation, apoptosis, and inducible gene expression following stress and
neuroendocrine stimulation. In the adult heart, calcineurin regulates hypertrophic growth of
cardiomyocytes in response to pathologic insults that are associated with altered Ca 2+
handling. Here we determined that calcineurin signaling is directly linked to the proper …