[HTML][HTML] Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo
S Kir, Y Zhang, RD Gerard, SA Kliewer… - Journal of Biological …, 2012 - ASBMB
Fibroblast growth factor 19 (FGF19) is a postprandial enterokine induced by the nuclear bile
acid receptor, FXR, in ileum. FGF19 inhibits bile acid synthesis in liver through
transcriptional repression of cholesterol 7α-hydroxylase (CYP7A1) via a mechanism
involving the nuclear receptor SHP. Here, in a series of loss-of-function studies, we show
that the nuclear receptors HNF4α and LRH-1 have dual roles in regulating Cyp7a1 in vivo.
First, they cooperate in maintaining basal Cyp7a1 expression. Second, they enable SHP …
acid receptor, FXR, in ileum. FGF19 inhibits bile acid synthesis in liver through
transcriptional repression of cholesterol 7α-hydroxylase (CYP7A1) via a mechanism
involving the nuclear receptor SHP. Here, in a series of loss-of-function studies, we show
that the nuclear receptors HNF4α and LRH-1 have dual roles in regulating Cyp7a1 in vivo.
First, they cooperate in maintaining basal Cyp7a1 expression. Second, they enable SHP …