Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer
JA Blansfield, KE Beck, K Tran, JC Yang… - Journal of …, 2005 - journals.lww.com
Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule
expressed by activated T cells and resting CD4+ CD25+ T cells. In patients with advanced
melanoma, our group reported that administration of anti-CTLA-4 antibody mediated
objective cancer regression in 13% of patients. This study also established that the blockade
of CTLA-4 was associated with grade III/IV autoimmune manifestations that included
dermatitis, enterocolitis, hepatitis, uveitis, and a single case of hypophysitis. Since this initial …
expressed by activated T cells and resting CD4+ CD25+ T cells. In patients with advanced
melanoma, our group reported that administration of anti-CTLA-4 antibody mediated
objective cancer regression in 13% of patients. This study also established that the blockade
of CTLA-4 was associated with grade III/IV autoimmune manifestations that included
dermatitis, enterocolitis, hepatitis, uveitis, and a single case of hypophysitis. Since this initial …