The tumor microenvironment is a complex framework, in which myeloid cells play important
roles in sculpting cancer development from tumor initiation to metastasis. Immune cells are
key participants of the tumor microenvironment where they can promote or inhibit cancer
formation and development. Plasticity is a widely accepted hallmark of myeloid cells and in
particular of the monocyte–macrophage lineage. It includes the ability to display a wide
spectrum of activation states in response to distinct signals and classical M1 or alternative …