[CITATION][C] The concept of immunological surveillance

FM Burnet - Immunological Aspects of Neoplasia, 1970 - karger.com
FM Burnet
Immunological Aspects of Neoplasia, 1970karger.com
The concept of immunological surveillance has been developed over at least the past dozen
years. Essential background work goes back much farther—to the first recognition [Little,
1941] that pure-line mice must be used if reproducible results were to be obtained in the
study of transplantable cancers. Most of the rules of histocompatibility were worked out using
tumor transplants long before skin transplantation became a standard laboratory procedure.
It was obvious that rejection of a tumor of allogeneic
The concept of immunological surveillance has been developed over at least the past dozen years. Essential background work goes back much farther—to the first recognition [Little, 1941] that pure-line mice must be used if reproducible results were to be obtained in the study of transplantable cancers. Most of the rules of histocompatibility were worked out using tumor transplants long before skin transplantation became a standard laboratory procedure. It was obvious that rejection of a tumor of allogeneic
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