Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology
SQ Yang, HZ Lin, AK Mandal, J Huang, AM Diehl - Hepatology, 2001 - journals.lww.com
The impaired regenerative capacity of fatty livers might promote the progression of
nonalcoholic fatty liver disease (NAFLD). To identify mechanisms involved, regenerative
responses were compared in normal mice and ob/ob mice (a model for NAFLD) after partial
hepatectomy (PH). We hypothesized that the usual PH activation of oxidant-sensitive, growth-
regulatory kinase cascades would be abnormal in fatty hepatocytes, which have adapted to
chronic oxidant stress, and expected that this might interfere with the induction of …
nonalcoholic fatty liver disease (NAFLD). To identify mechanisms involved, regenerative
responses were compared in normal mice and ob/ob mice (a model for NAFLD) after partial
hepatectomy (PH). We hypothesized that the usual PH activation of oxidant-sensitive, growth-
regulatory kinase cascades would be abnormal in fatty hepatocytes, which have adapted to
chronic oxidant stress, and expected that this might interfere with the induction of …