[HTML][HTML] An experimental model for the study of well-differentiated and dedifferentiated liposarcoma; deregulation of targetable tyrosine kinase receptors
T Peng, P Zhang, J Liu, T Nguyen, S Bolshakov… - Laboratory …, 2011 - Elsevier
Therapeutic progress in well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) is
hampered by lack of relevant experimental models, thereby limiting comprehensive
molecularly based investigations. Our goal is to bridge this experimental gap by establishing
and characterizing an in vitro/in vivo model useful for examining WDLPS/DDLPS molecular
pathogenesis and also therapeutic screening and testing. WDLPS/DDLPS cells were
isolated from freshly resected human surgical specimens and were phenotypically and …
hampered by lack of relevant experimental models, thereby limiting comprehensive
molecularly based investigations. Our goal is to bridge this experimental gap by establishing
and characterizing an in vitro/in vivo model useful for examining WDLPS/DDLPS molecular
pathogenesis and also therapeutic screening and testing. WDLPS/DDLPS cells were
isolated from freshly resected human surgical specimens and were phenotypically and …