[HTML][HTML] Isoform specificity among ankyrins: an amphipathic α-helix in the divergent regulatory domain of ankyrin-B interacts with the molecular co-chaperone Hdj1 …
Ankyrins-R,-B, and-G are a family of membrane-associated adaptors required for
localization of structurally diverse proteins to specialized membrane domains, including
axon initial segments, cardiomyocyte T-tubules, and epithelial cell lateral membranes.
Ankyrins are often co-expressed in the same cells and, although structurally similar, have
non-overlapping functions. We previously determined that the regulatory domain of ankyrin-
B defines specificity between ankyrins B and G in cardiomyocytes. Here, we identify key …
localization of structurally diverse proteins to specialized membrane domains, including
axon initial segments, cardiomyocyte T-tubules, and epithelial cell lateral membranes.
Ankyrins are often co-expressed in the same cells and, although structurally similar, have
non-overlapping functions. We previously determined that the regulatory domain of ankyrin-
B defines specificity between ankyrins B and G in cardiomyocytes. Here, we identify key …