Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burns
K Aoki, N Aikawa, K Sekine, M Yamazaki, T Mimura… - Burns, 2001 - Elsevier
To clarify the role of plasminogen activator inhibitor type 1 (PAI-1) in postburn
hypercoagulation, we assayed the plasma levels of tissue-type plasminogen activator (t-PA)
antigen, total PAI-1 antigen, and total t-PA-PAI-1 complex in 15 burned patients. The total
body surface area of the burn injury ranged from 30 to 80%. Serial blood samples were
collected from 12 to 168 h following the thermal injury. The plasma t-PA level and the free
PAI-1 level increased significantly in the immediate postburn period, and the percent …
hypercoagulation, we assayed the plasma levels of tissue-type plasminogen activator (t-PA)
antigen, total PAI-1 antigen, and total t-PA-PAI-1 complex in 15 burned patients. The total
body surface area of the burn injury ranged from 30 to 80%. Serial blood samples were
collected from 12 to 168 h following the thermal injury. The plasma t-PA level and the free
PAI-1 level increased significantly in the immediate postburn period, and the percent …