[HTML][HTML] A novel mechanism by which interferon-γ can regulate interleukin (IL)-13 responses: evidence for intracellular stores of IL-13 receptor α-2 and their rapid …
MO Daines, GKK Hershey - Journal of Biological Chemistry, 2002 - ASBMB
Interleukin (IL)-13 mediates its activities via a complex receptor system. Interleukin-13
receptor α-1 chain (IL-13Rα1) binds IL-13 with low affinity, but does not signal. However,
when IL-13Rα1 combines with IL-4 receptor α (IL-4Rα), a signaling high affinity receptor
complex for IL-13 is generated. In contrast, IL-13Rα2 alone binds IL-13 with high affinity, but
does not signal and has been postulated to be a decoy receptor. Herein, we investigated the
cellular localization of IL-13Rα2 and the regulation of its expression by confocal microscopy …
receptor α-1 chain (IL-13Rα1) binds IL-13 with low affinity, but does not signal. However,
when IL-13Rα1 combines with IL-4 receptor α (IL-4Rα), a signaling high affinity receptor
complex for IL-13 is generated. In contrast, IL-13Rα2 alone binds IL-13 with high affinity, but
does not signal and has been postulated to be a decoy receptor. Herein, we investigated the
cellular localization of IL-13Rα2 and the regulation of its expression by confocal microscopy …