[HTML][HTML] Retinoschisin, a new binding partner for L-type voltage-gated calcium channels in the retina

L Shi, K Jian, ML Ko, D Trump, GYP Ko - Journal of biological chemistry, 2009 - ASBMB
The L-type voltage-gated calcium channels (L-VGCCs) are activated under high
depolarization voltages. They are vital for diverse biological events, including cell
excitability, differentiation, and synaptic transmission. In retinal photoreceptors, L-VGCCs
are responsible for neurotransmitter release and are under circadian influences. However,
the mechanism of L-VGCC regulation in photoreceptors is not fully understood. Here, we
show that retinoschisin, a highly conserved extracellular protein, interacts with the L …