In vitro contractile effect of platelet-activating factor on guinea-pig myometrium
G Montrucchio, G Alloatti, C Tetta, C Roffinello… - Prostaglandins, 1986 - Elsevier
Platelet-activating factor (PAF) evoked myometrial contractions in two different patterns,
depending on whether spontaneous activity was present. In spontaneously active
myometrial strips (58%), both PAF and oxytocin enhanced the amplitude of myometrial
contractions. In quiescent myometrial strips, PAF induced contractions characterized by a
prompt development of tension, a plateau, and a final, rapid relaxation. In 54% of these
strips, PAF-induced contraction was followed by rhythmic activity. PAF contractile response …
depending on whether spontaneous activity was present. In spontaneously active
myometrial strips (58%), both PAF and oxytocin enhanced the amplitude of myometrial
contractions. In quiescent myometrial strips, PAF induced contractions characterized by a
prompt development of tension, a plateau, and a final, rapid relaxation. In 54% of these
strips, PAF-induced contraction was followed by rhythmic activity. PAF contractile response …