[HTML][HTML] Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis [S]
BL Vaisman, SJ Demosky, JA Stonik, M Ghias… - Journal of lipid …, 2012 - ASBMB
The role of endothelial ABCA1 expression in reverse cholesterol transport (RCT) was
examined in transgenic mice, using the endothelial-specific Tie2 promoter. Human ABCA1
(hABCA1) was significantly expressed in endothelial cells (EC) of most tissues except the
liver. Increased expression of ABCA1 was not observed in resident peritoneal macrophages.
ApoA-I-mediated cholesterol efflux from aortic EC was 2.6-fold higher (P< 0.0001) for cells
from transgenic versus control mice. On normal chow diet, Tie2 hABCA1 transgenic mice …
examined in transgenic mice, using the endothelial-specific Tie2 promoter. Human ABCA1
(hABCA1) was significantly expressed in endothelial cells (EC) of most tissues except the
liver. Increased expression of ABCA1 was not observed in resident peritoneal macrophages.
ApoA-I-mediated cholesterol efflux from aortic EC was 2.6-fold higher (P< 0.0001) for cells
from transgenic versus control mice. On normal chow diet, Tie2 hABCA1 transgenic mice …