MicroRNA-155 modulates Th1 and Th17 cell differentiation and is associated with multiple sclerosis and experimental autoimmune encephalomyelitis
J Zhang, Y Cheng, W Cui, M Li, B Li, L Guo - Journal of neuroimmunology, 2014 - Elsevier
Mammalian noncoding microRNAs (miRNAs) are suggested to be involved in immune
system function. We found that miR-155 expression was highly correlated with disease
severity in patients with multiple sclerosis and mice with experimental autoimmune
encephalomyelitis (EAE). Knockdown of miR-155 resulted in low Th1 and Th17 cells and
mild EAE, and its overexpression led to more Th1 and Th17 cells and severe EAE. MiR-155
promoted the development of inflammatory Th17/Th1 cell subsets. These findings …
system function. We found that miR-155 expression was highly correlated with disease
severity in patients with multiple sclerosis and mice with experimental autoimmune
encephalomyelitis (EAE). Knockdown of miR-155 resulted in low Th1 and Th17 cells and
mild EAE, and its overexpression led to more Th1 and Th17 cells and severe EAE. MiR-155
promoted the development of inflammatory Th17/Th1 cell subsets. These findings …