[HTML][HTML] miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation
The miR-17-92 cluster regulates a broad spectrum of biological processes of T cell
immunity. This cluster was found to facilitate T cell proliferation, enhance antitumor activities
and promote T cell-dependent antibody responses. However, little is known about the role of
this miRNA cluster in the development of autoimmune diseases. Multiple sclerosis is a neuro-
destructive autoimmune disease caused by the pathogenicity of TH 17 cells, whose
differentiation is tightly controlled by a variety of transcriptional and post-transcriptional …
immunity. This cluster was found to facilitate T cell proliferation, enhance antitumor activities
and promote T cell-dependent antibody responses. However, little is known about the role of
this miRNA cluster in the development of autoimmune diseases. Multiple sclerosis is a neuro-
destructive autoimmune disease caused by the pathogenicity of TH 17 cells, whose
differentiation is tightly controlled by a variety of transcriptional and post-transcriptional …