Unconventional recognition of peptides by T cells and the implications for autoimmunity
JF Mohan, ER Unanue - Nature Reviews Immunology, 2012 - nature.com
JF Mohan, ER Unanue
Nature Reviews Immunology, 2012•nature.comThe interaction of antigen-presenting cells with free peptides or a denatured protein can give
rise to peptide–MHC class II complexes that are distinct from those generated after the
processing of the whole protein. Such atypical peptide–MHC complexes can be recognized
by unconventional'type B'T cells that are not a component of the normal immune response to
proteins. Importantly, these unconventional T cells can be found in the setting of
autoimmunity. Here, we discuss unconventional peptide recognition by type BT cells and …
rise to peptide–MHC class II complexes that are distinct from those generated after the
processing of the whole protein. Such atypical peptide–MHC complexes can be recognized
by unconventional'type B'T cells that are not a component of the normal immune response to
proteins. Importantly, these unconventional T cells can be found in the setting of
autoimmunity. Here, we discuss unconventional peptide recognition by type BT cells and …
Abstract
The interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide–MHC class II complexes that are distinct from those generated after the processing of the whole protein. Such atypical peptide–MHC complexes can be recognized by unconventional 'type B' T cells that are not a component of the normal immune response to proteins. Importantly, these unconventional T cells can be found in the setting of autoimmunity. Here, we discuss unconventional peptide recognition by type B T cells and consider the implications for type 1 diabetes and other autoimmune diseases.
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