Mechanisms of antibody immunotherapy on clonal islet reactive T cells
P Van De Linde, OMH Tysma, JP Medema, G Hale… - Human immunology, 2006 - Elsevier
Clinical intervention trials evaluating the efficacy of antibody immunotherapy in type 1
diabetes are in progress. We tested effects on prediabetic islet antigen-specific autoreactive
T cells of antithymocyte globulin (ATG) and humanized monoclonal antibodies against CD3
(ChAglyCD3) or CD25 (daclizumab) with regard to downmodulation of the target protein,
proliferation, cytokine production, complement-dependent cytotoxicity (CDC), antibody-
dependent cell cytotoxicity (ADCC), and survival. ATG leads to depletion of autoreactive …
diabetes are in progress. We tested effects on prediabetic islet antigen-specific autoreactive
T cells of antithymocyte globulin (ATG) and humanized monoclonal antibodies against CD3
(ChAglyCD3) or CD25 (daclizumab) with regard to downmodulation of the target protein,
proliferation, cytokine production, complement-dependent cytotoxicity (CDC), antibody-
dependent cell cytotoxicity (ADCC), and survival. ATG leads to depletion of autoreactive …