[HTML][HTML] Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters
J Castro-Perez, F Briand, K Gagen, SP Wang… - Journal of lipid …, 2011 - ASBMB
Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester (CE) and triglyceride
between HDL and apoB-containing lipoproteins. Anacetrapib (ANA), a reversible inhibitor of
CETP, raises HDL cholesterol (HDL-C) and lowers LDL cholesterol in dyslipidemic patients;
however, the effects of ANA on cholesterol/lipoprotein metabolism in a dyslipidemic hamster
model have not been demonstrated. To test whether ANA (60mg/kg/day, 2 weeks) promoted
reverse cholesterol transport (RCT), 3 H-cholesterol-loaded macrophages were injected and …
between HDL and apoB-containing lipoproteins. Anacetrapib (ANA), a reversible inhibitor of
CETP, raises HDL cholesterol (HDL-C) and lowers LDL cholesterol in dyslipidemic patients;
however, the effects of ANA on cholesterol/lipoprotein metabolism in a dyslipidemic hamster
model have not been demonstrated. To test whether ANA (60mg/kg/day, 2 weeks) promoted
reverse cholesterol transport (RCT), 3 H-cholesterol-loaded macrophages were injected and …