[HTML][HTML] cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the Generation of CD3+ CD4− CD8− T cells
TCR-αβ+ CD3+ CD4− CD8−" double negative" T cells are expanded in the peripheral blood
of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative
T cells have been claimed to derive from CD8+ cells that down-regulate CD8 co-receptors
and acquire a distinct effector phenotype that includes the expression of proinflammatory
cytokines. This, along with the fact that double negative T cells have been documented in
inflamed organs, suggests that they may contribute to disease expression and tissue …
of patients with systemic lupus erythematosus (SLE) and lupus-prone mice. Double negative
T cells have been claimed to derive from CD8+ cells that down-regulate CD8 co-receptors
and acquire a distinct effector phenotype that includes the expression of proinflammatory
cytokines. This, along with the fact that double negative T cells have been documented in
inflamed organs, suggests that they may contribute to disease expression and tissue …