[HTML][HTML] cAMP-responsive element modulator (CREM) α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic …
IL-2 is a key cytokine during proliferation and activation of T lymphocytes and functions as
an auto-and paracrine growth factor. Regardless of activating effects on T lymphocytes, the
absence of IL-2 has been linked to the development of autoimmune pathology in mice and
humans. Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease and
characterized by dysregulation of lymphocyte function, transcription factor and cytokine
expression, and antigen presentation. Reduced IL-2 expression is a hallmark of SLE T …
an auto-and paracrine growth factor. Regardless of activating effects on T lymphocytes, the
absence of IL-2 has been linked to the development of autoimmune pathology in mice and
humans. Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease and
characterized by dysregulation of lymphocyte function, transcription factor and cytokine
expression, and antigen presentation. Reduced IL-2 expression is a hallmark of SLE T …