The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing

SL Gaffen, R Jain, AV Garg, DJ Cua - Nature reviews immunology, 2014 - nature.com
Nature reviews immunology, 2014nature.com
Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering
the molecular mechanisms of T cell lineage commitment and function. In this Review, we
focus on the recent advances that have been made regarding the transcriptional control of
TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we
highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues …
Abstract
Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues. We also discuss the emerging clinical data showing that IL-17-specific and IL-23-specific antibody treatments are remarkably effective for treating many immune-mediated inflammatory diseases.
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